"Among the people rumored to be a possibility for John McCain's vice-presidential running mate is 51-year-old Florida Governor Charlie Crist and surprisingly not his brother, Jesus Crist" --Seth Meyers
"As you know, last week the big rumor, according to the New York Times, is John McCain was allegedly sleeping with a a young, attractive lobbyist. Well, that story has pretty much gone away. In fact, the only one trying to keep it alive now? John McCain." --Jay Leno
"Obama and Hillary argued last night over which candidate the Republicans are most afraid of. Interesting. I don't want to take sides here, but I think it's pretty obvious which candidate Republicans are most afraid of, John McCain." --Jay Leno
"How about John McCain? He looks like a guy at a restaurant that says I'm leaving 10%, that's good enough. John McCain, looks like the guy that goes to the curb for the paper and locks himself outside of the house." --David Letterman
"The New York Times says that John McCain had a close, personal relationship with a beautiful, young, female lobbyist. Do you believe this? Think about it. A senator, who's a Republican having sex with a woman." --Jay Leno
"If it does turn out to be true, then John McCain's critics have a point -- he really does act more like a Democrat." --Jay Leno
"They say this woman works for the telecommunications lobby. Apparently, she called McCain out of the blue and asked, 'Are you happy with your current sex provider?'" --Jay Leno
"The New York Times this week printed an article alleging that John McCain may have had an improper affair with lobbyist Vicki Iseman. Or, as it's known among lobbyists, lobbying." --Amy Poehler
"The New York Times is claiming that John McCain, who is 71 years old, had an inappropriate relationship with a woman who is a Washington lobbyist. The good news is there's no footage. Political experts say this could be a huge scandal for McCain because he's married and the woman he's accused of having an affair with is 31 years younger than he is. In a related story, earlier today McCain was endorsed by Bill Clinton." --Conan O'Brien
"I mean, think about it, John McCain and with a young blond, and this was interesting: out of force of habit, Hillary is standing by him." --David Letterman
"But seriously how about that John McCain? John McCain looks like a guy whose head you can barely see over the steering wheel. ... John McCain looks like the guy who thinks the nurses are stealing his stuff. 'Dad, why would they take your socks? It doesn't make sense.'" --David Letterman
"John McCain seems reinvigorated. He has a new campaign slogan, 'He'll lead you into the 21st century.' I like it better than the old slogan, which was 'He'll lead you into assisted living.'" --David Letterman
"There was a big story in The New York Times today about Senator John McCain, who's running for president. It questioned his ties to a lobbyist named Vicki Iseman. The story 'hinted' that McCain may have had an extramarital affair with her, but the weird thing is she looks almost exactly like John McCain's wife, Cindy. So he might have just got confused and grabbed the wrong woman. These two look more alike than the Olson twins." --Jimmy Kimmel
"The New York Times printed a story that said ... in John McCain's last campaign in 2000, he was apparently acting so sprung on a lobbyist lady that his staff had to c---block the senior citizen from Arizona from sweeping this chick right off her feet and onto his motorized shopping cart. ... John McCain's pick-up line is, 'Did you know that 150 is the new 130?'" --Bill Maher
"I think this is a cynical attempt by the McCain campaign to make their candidate appear youthful and vigorous. I think they made the whole thing up and filtered it through the New York Times. You know, just like Bush did with the weapons of mass destruction in Iraq. ... Because there's no real evidence to this story. Yes, a lot of people saw McCain going around with a cheap blond in a slinky dress, but they figured it was Rudy Giuliani." --Bill Maher
"They have debated so much that they are now debating about debating. Did you see this? A lot of this debate was about the power of words. Hillary said, 'Actions speak louder than words,' Then Obama said, 'Words can speak as loud as actions.' And then McCain said, 'Speak louder!'" --Bill Maher
"How about this John McCain, huh? Whoa, my gosh - doesn't he look like the old guy at the barber shop? He looks kind of like a Wal-Mart greeter, John McCain. He kind of looks like the neighbor who says, 'Oh, that dead tree is on your property,' one of those guys. He's the guy who is always early for the early bird special, that's what he looks like. He looks like a mall walker, ladies and gentlemen. He looks like the guy at the supermarket who is confused by the automatic doors. He looks like the uncle who pretends to remove his thumb." --David Letterman
"Senator John McCain has unveiled a new campaign slogan -- 'Ready To Lead America Into The 21st Century.' Yeah, yeah. And this is a lot better than his old slogan, 'I've Been Around Since The 19th Century.'" --Conan O'Brien
"I like John McCain. He looks like an old guy in a coffee shop who's still complaining about the designated hitter. ... He looks like the guy who asks the driver if he's on the right bus. ... Who looks like the guy who's always saying, 'What was that? Nothing? That's what I thought.'" --David Letterman
"This campaign is kind of fascinating, because the three major candidates have to be very careful when they criticize each other. Like, you can't criticize Hillary. Ooh, that's sexism. You can't criticize Barack. Ooh, that's racism. And you can't go after McCain, because that's elder abuse." --Jay Leno
"After John McCain swept yesterday's primaries he purposely stole a line Barack Obama's been using, 'I'm fired up and ready to go.' When Obama heard this he stole a line McCain's been using, 'I'm old and not sure where I am.'" --Conan O'Brien
"John McCain was the big Republican winner. One pundit said McCain's lucky nickel was working. He carries a lucky nickel. It must be lucky -- six months ago, that was his campaign war chest." --Jay Leno

